PopMuse: Pathology and Medicine http://popmu.se Musings of stuff en-us Copyright 2007-2020 http://creativecommons.org/licenses/by-nc-sa/3.0/ Ethnicity and covid-19: analysis must be inclusive and transparent http://feeds.bmj.com/~r/bmj/recent/~3/_4Icmf__aXU/bmj.m2166.short http://feeds.bmj.com/~r/bmj/recent/~3/_4Icmf__aXU/bmj.m2166.short Mon, 01 Jun 2020 08:51:15 UTC Padmasayee Papineni, Tiffanie Harrison, Juliette Mutuyimana at Latest headlines from BMJ Khunti and colleagues discuss the possible association between ethnicity and severity of covid-19.1 Our experience in London would suggest such a link, and further analysis of clinical outcomes data... http://creativecommons.org/licenses/by-nc-sa/3.0/ UK hospitals to trial five new drugs in search for coronavirus treatment https://www.theguardian.com/world/2020/jun/01/uk-hospitals-trial-five-new-drugs-search-coronavirus-treatment https://www.theguardian.com/world/2020/jun/01/uk-hospitals-trial-five-new-drugs-search-coronavirus-treatment Mon, 01 Jun 2020 06:00:33 UTC Lisa O'Carroll at Medical research | The Guardian Exclusive: thirty hospitals looking to sign up hundreds of patients to take part in studiesCoronavirus – latest updatesSee all our coronavirus coverageFive new drugs are to be trialled in 30 hospitals across the country in the race to find a treatment for Covid-19, it has emerged.Just days after global trials of hydroxychloroquine, the drug promoted by Donald Trump as a cure, were halted, British scientists are looking to sign up hundreds of patients for trials of medicines they hope will prevent people becoming ill enough to need intensive care or ventilators.Heparin, a blood-thinning drug used in hospitals up and down the country. It will be given to Covid-19 patients for the first time next month. In a number of conditions it has been shown that if it is nebulised rather than injected, it can “have a dramatic effect in the lung”, said Wilkinson. “It is a big sticky molecule which can attach to viruses and stop them from entering cells and secondly it may have an important anti-inflammatory effect”. Tests of Heparin will be highly anticipated because it is already widely used, shown to be widely tolerated, and is naturally occurring and therefore can be produced cheaply in huge quantities if proven to be effective.�Bemcentinib, a tablet developed by the Norwegian company BerGenBio, which is used to treat blood disorders. “It has been shown, almost by chance, to have a potent antiviral effect” to reduce infection in experiments on a number of viruses including Ebola and Sars coronavirus-2, said Wilkinson. It appears to work by preventing the virus infecting the cells but also by reducing its replication within healthy cells by keeping the innate immunity created by type 1 interferon proteins active. Healthy cells usually “switch off the entire machinery so the virus can’t hijack it”, said Wilkinson, but Covid-19 “subverts this” and this drug may help cells against viral attack, he added.�Medi3506, an anti-inflammatory injection being developed for skin disorders and chronic obstructive pulmonary disease, but which has also been used in trials for asthma by AstraZeneca.�It acts to dampen down the cytokine storm that causes the immune system to go into overdrive and cause fever, inflammation and fatigue.Calquence, another AstraZeneca drug, used to treat mantle cell lymphoma. It acts as an inhibitor of the enzyme known as Bruton’s tyrosine kinase (BRK) and was developed for severe lung inflammation. It was chosen for a formal trial after anecdotal evidence showed a reduced incidence of complications from Covid infection or severe lung injuries.Zilucoplan, a drug developed by the Belgian biopharma company UCB, which is already in trial for potential treatment of myasthenia gravis, a skeleto-muscular disorder. Hopes centre on its ability to stop the overactivation of “complement cascade”, part of the immune system that can kill cells and lead to catastrophic lung and tissue damage. “A lot of the damage is focused on the blood cells and the very small blood vessels in the lung.” Continue reading... http://creativecommons.org/licenses/by-nc-sa/3.0/ Contents https://www.medicinejournal.co.uk/article/S1357-3039(20)30101-8/fulltext?rss=yes https://www.medicinejournal.co.uk/article/S1357-3039(20)30101-8/fulltext?rss=yes Mon, 01 Jun 2020 00:00:00 UTC Medicine http://creativecommons.org/licenses/by-nc-sa/3.0/ Editorial Board https://www.medicinejournal.co.uk/article/S1357-3039(20)30103-1/fulltext?rss=yes https://www.medicinejournal.co.uk/article/S1357-3039(20)30103-1/fulltext?rss=yes Mon, 01 Jun 2020 00:00:00 UTC Medicine http://creativecommons.org/licenses/by-nc-sa/3.0/ Spanish PM seeks final extension to state of emergency – as it happened https://www.theguardian.com/world/live/2020/may/31/coronavirus-live-news-global-cases-pass-6-million-as-brazil-sees-record-one-day-increase https://www.theguardian.com/world/live/2020/may/31/coronavirus-live-news-global-cases-pass-6-million-as-brazil-sees-record-one-day-increase Sun, 31 May 2020 23:10:32 UTC Clea Skopeliti (now), Caroline Davies, Ben Quinn and Helen Sullivan (earlier) at Medical research | The Guardian US sends Brazil 2m doses of hydroxychloroquine, despite safety fears; pressure builds on South African president. This blog is now closed please follow our continuing live coverage belowCoronavirus live coverage 12.37am BSTWe are closing this blog now but you can stay up to date on all of our live coverage of the coronavirus pandemic at our new global blog below. https://www.theguardian.com/world/live/2020/jun/01/coronavirus-live-news-brazil-passes-500000-covid-19-cases-as-india-extends-lockdown-in-high-risk-zones 12.10am BSTThat’s all from me, Clea Skopeliti, for today. Many thanks to everyone who wrote in. I’m handing over to my colleague Alison Rourke in Sydney. 11.21pm BSTPoverty in the occupied West Bank may double as Palestinians are slammed by the economic fallout of the coronavirus pandemic, the World Bank has warned.The Palestinian territories have seen low infection rates after acting quickly to curtail the spread of Covid-19, with three deaths out of 450 cases registered among some five million residents in Gaza and the West Bank, AFP reports. 10.42pm BSTThe US has supplied Brazil with 2 million doses of the anti-malaria drug hydroxychloroquine for use against the coronavirus, despite medical warnings about the risks associated with it.The two governments released a joint announcement just days after the WHO suspended testing it on Covid-19 patients due to health concerns. Both presidents have promoted its use, despite the US Food and Drug Administration issuing a warning about its use against the virus. 10.13pm BSTEgypt has shortened its night curfew by one hour despite recording high daily increases in both deaths and cases. The health ministry announced 1,536 new cases had been confirmed, including 46 deaths. The total caseload now stands at 24,985, while the toll is at 959. 9.51pm BSTBrazilian president Jair Bolsonaro joined a rally on Sunday on horseback as supporters called for the Supreme Court to be shut down for investigating the right-wing leader, as one of its justices compared the risks to Brazil’s democracy with Hitler’s Germany.Deepening a political crisis during one of the world’s worst coronavirus outbreaks, Bolsonaro has slammed the top court for investigating his interference in police affairs and opening an inquiry into his supporters’ alleged libel and intimidation campaigns on social media. 9.42pm BSTYou can get in touch with me on Twitter @cleaskopeliti. 9.16pm BSTThe US Centers for Disease Control and Prevention (CDC) on Sunday reported a total 1,761,503 cases of the coronavirus, an increase of 23,553 cases from its previous count, and said that the number of deaths in the country had risen by 915 to 103,700.The CDC figures do not necessarily reflect cases reported by individual states. 9.08pm BSTHere’s a quick summary for those who are just waking up, or anyone else looking for a wee recap. Related: Coronavirus latest: at a glance 8.35pm BSTWhile the rest of India prepares to reopen, individual states are identifying high-risk zones where lockdowns will stay in place.Prime minister Narendra Modi’s government has extended lockdown until 30 June in these ‘containment’ zones that continue to report high infection numbers. Outside the zones, restaurants, malls and religious buildings will be allowed to reopen from 8 June, in a relaxation of the world’s longest coronavirus lockdown. 8.19pm BSTThe airport in the Namibian harbour town of Walvis Bay has closed after two people tested positive for the coronavirus and the economic hub went into lockdown.The airport would be closed for seven days, manager Chrizelda George told media on Sunday. 7.57pm BSTSouth Africa has pushed back Monday’s reopening of schools by a week, the Department of Basic Education has announced, saying that many are not ready to welcome back pupils.The plan for grades 7 and 12, the last years of primary and secondary school respectively, to return on Monday were scrapped following teachers’ unions and governing associations urging school staff to defy the government order, saying schools did not have protective equipment to keep educators and pupils safe. 7.49pm BSTMore that 1,000 people have died from the coronavirus in Chile, the health ministry has reported, with 827 of the deaths occurring in May alone.The country has had 99,688 confirmed cases of the disease so far, and 1,054 deaths. 7.35pm BSTEl Salvador’s Congress has passed a new emergency bill to address the impact of the coronavirus crisis and gradually reopen the Central American nation’s economy, while president Nayib Bukele has vowed to veto the measure.Bukele argues it is too risky to reopen the country at this juncture. The country has registered 46 deaths from coronavirus and a total of 2,517 cases. 7.15pm BSTBosnia’s state court has ordered the release of a regional prime minister and two other men suspected of corruption in connection with the import of defective ventilators for coronavirus patients.The court of Bosnia-Herzegovina said their detention was unnecessary, and turned down the prosecution’s requests to detain the three men for 30 days. 6.55pm BSTSenior public health officials have made a last-minute plea for ministers to scrap Monday’s easing of the coronavirus lockdown in England, warning the country is unprepared to deal with any surge in infection and that public resolve to take steps to limit transmission has been eroded.The Association of Directors of Public Health said new rules, including allowing groups of up to six people to meet outdoors and in private gardens, were “not supported by the science” and that pictures of crowded beaches and beauty spots over the weekend showed “the public is not keeping to social distancing as it was”. Related: Health officials make last-minute plea to stop lockdown easing in England 6.47pm BSTAround 65% of small Israeli start-ups expect to cease operations in the next six months due to the economic impact of the coronavirus crisis, a poll has shown.The survey, conducted by the Israeli Innovation Authority - a state agency that finances start-ups - and a group of tech industries, paints a gloomy picture of future in the self-styled “start-up nation”, where the high-tech sector accounts for 10% of jobs. 6.38pm BSTCrowds of protesters gathered in parts of the UK in solidarity with the unrest across the US after the killing of George Floyd. In London, hundreds gathered in Trafalgar Square before marching to the US embassy. As they walked chants could be heard of ‘I can’t breathe’ and the name of the organisers, Black Lives Matter. 6.27pm BSTHere are some of the key coronavirus developments from over the last few hours. 6.19pm BSTFrance’s coronavirus cases are continuing to decline, health officials have said, with 14,322 patients currently in hospital, down from 14,380 a day earlier.The number of Covid-19 patients in intensive care fell to 1,319 from 1,361, the health directorate said in a statement. The hospital death toll from the virus rose by 31 to 18,475, which represents the 11th consecutive daily increase below 100. 6.13pm BSTHello, I’m Clea Skopeliti and I’ll be running the live blog for the next few hours. Please feel free to reach me on Twitter @cleaskopeliti, or by email, with any news tips or comments. Thanks in advance. 6.10pm BSTThe Al-Aqsa Mosque in Jerusalem, Islam’s holiest site outside of Saudi Arabia, reopened on Sunday for prayers for the first time since it was closed in mid-March.With little regard for social distancing, throngs waited outside the holy site’s gates before it opened early on Sunday, with many wearing surgical masks, the Associated Press reports. 5.40pm BSTAbu Dhabi announced on Sunday it will cordon off the UAE’s capital as well as banning travel between regions within the emirate for a week from Tuesday to rein in coronavirus. It means that residents of the United Arab Emirates will not be allowed to travel from the capital Abu Dhabi to the services hub of Dubai, 90 minutes on a major highway, without a permit. 5.09pm BSTThe Guardian report on the major global coronavirus developments on Sunday can be read here. 4.41pm BSTBangladesh lifted its coronavirus lockdown on Sunday, with millions heading back to work in densely populated cities and towns even as the country logged a record spike in deaths and new infections, AFP reports.“The lockdown has been lifted and we are heading almost towards our regular life,” health department spokeswoman Nasima Sultana said, calling on those returning to work to wear masks and observe social distancing. 4.21pm BSTIn the UK, the Department of Health said 38,489 people had died in hospitals, care homes and the wider community after testing positive for coronavirus as of 5pm on Saturday, up by 113 from 38,376 the day before.In the 24-hour period up to 9am on Sunday, 115,725 tests were carried out or dispatched with 1,936 positive results. 3.41pm BSTSome of Italy’s famous cultural sites are coming back to life after being closed for more than three months owing to the coronavirus pandemic, Angela Giuffrida in Rome writes. The Leaning Tower of Pisa reopened on Saturday while the Colosseum and Vatican Museums will welcome visitors again from Monday, and Florence’s Uffizi gallery from Tuesday. 3.31pm BSTEgyptian hotels operating with a new reduced occupancy rate of 25% to contain the spread of coronavirus have almost reached full capacity, a tourism ministry official told Reuters on Sunday.Egypt suspended international flights in March and shut down restaurants, hotels and cafes in order to combat the pandemic. Although airports remain closed to all but domestic and repatriation flights, hotels were recently allowed to reopen at a quarter of their usual capacity if they met strict health and safety protocols.Around 78 hotels, mostly along the Red Sea coast, met these rules and are currently operating with an occupancy rate of 20%-22%, said the ministry official, who spoke to Reuters on condition of anonymity. An additional 173 hotels across the country have applied for a licence to reopen and will be considered in the coming week, he added. 3.09pm BSTIran said its caseload of coronavirus infections passed 150,000 on Sunday, as the country struggles to contain a recent upward trend.The government has largely lifted the restrictions it imposed in order to halt a COVID-19 outbreak that first emerged in mid-February. 2.35pm BSTParis is gearing up for a battle for public space after the city’s mayor, Anne Hidalgo, said cafes, bars and restaurants would be temporarily allowed to set up tables on pavements and in parking spaces when they open this week, Kim Willsher in Paris reports. Coronavirus lockdown measures are being eased further on Tuesday, with food and drink establishment opening across most of France for the first time since 14 March. However, because Paris remains “orange” on the country’s Covid-19 map, meaning the virus is still circulating, bar, cafe and restaurant owners have been told they can only serve customers outside on terraces and with strict physical distancing and protection measures in place. 2.06pm BSTThailand has passed a record stimulus package of nearly $60 billion to revive its economy which has been hammered by the coronavirus. Thailand’s parliament approved the 1.9 trillion baht ($59.7 billion) package - the kingdom’s biggest-ever cash injection - on Sunday. 1.44pm BSTSpain’s prime minister, Pedro S�nchez, has just confirmed that his socialist-led coalition government will seek a sixth and final extension of the coronavirus state of emergency, which will run until 21 June. [See previous post at 10.37] .S�nchez said a last, two-week extension of the the emergency powers, in effect since 14 March, was needed and warned against complacency. We cannot forget the thousands of lives lost to Covid-19. I ask for prudence and respect for the health rules.”We need to go the final distance to end the health emergency. Today we need a final, definitive extension of the state of emergency, which will be lighter [than previous ones].” 12.55pm BSTA French care home has found an imaginative way of helping loved ones connect during the Covid-19 pandemic. You can watch the Reuters video here.WATCH: A French care home is helping families meet and hold each other again inside a plastic ‘happiness bubble’ pic.twitter.com/J35Sj55B39 12.13pm BSTPope Francis is cautioning against pessimism as many people emerge from lockdowns to lament that nothing will ever be the same, AP reports. During Mass in St. Peters Basilica to mark Pentecost Sunday, Francis noted a tendency to say nothing will return as before. That kind of thinking, Francis said, guarantees that the one thing that certainly does not return is hope.He took to task his own church for its fragmentation, saying it must pull together.The world sees conservatives and progressives but instead all are children of God,” he said, telling the faithful to focus on what unites them.In this pandemic, how wrong narcissism is, Francis said, lamenting the tendency to think only of our needs, to be indifferent to those of others, and to not admit our own frailties and mistakes.At this moment, in the great effort of beginning anew, how damaging is pessimism, the tendency to see everything in the worst light and to keep saying that nothing will return as before! the pope said. When someone thinks this way, the one thing that certainly does not return is hope.’’A few dozen faithful, wearing masks and sitting one to a pew, attended the ceremony as part of safety measures to avoid spreading COVID-19.While the Vatican has re-opened the basilica to tourists, the rank-and-file faithful still aren’t allowed yet to attend Masses celebrated by the pope for fear of crowding. 12.02pm BSTA German engineer on the first flight carrying European workers back to China has tested positive for coronavirus as an asymptomatic carrier, local authorities said Sunday.The man was on a Lufthansa flight from Frankfurt to the northeastern city of Tianjin which landed with around 200 passengers, mainly German workers and their families, AFP reports. 11.50am BSTThe Italian ‘orange vest’ movement held several protests across Italy on Saturday, including in Milan and Bergamo, two cities in the epicentre of Italy’s coronavirus pandemic, demanding a new government and return to the Italian Lira while dismissing Covid-19 as a conspiracy.Hundreds of people gathered at Milan’s Piazza del Duomo, many without wearing masks and flouting physical distancing rules, triggering anger and calls for them to be charged. 11.33am BSTHi. This is Caroline Davies. I am taking over the blog now and you can contact me on caroline.davies@theguardian.com 11.28am BST• The world has passed the milestone of six million confirmed coronavirus cases, with 6,048,384 confirmed infections worldwide, according to the Johns Hopkins University tracker. The US is the worst-affected country in terms of cases and deaths, with 1,769,776 infections and 103,685 fatalities.• In a dramatic pivot, US president Donald Trump has postponed the Group of Seven summit that he wanted to hold in June. He will also expand the list of countries invited to attend the rescheduled event to include Australia, Russia, South Korea and India. Speaking to reporters on Air Force One during his return to Washington from Cape Canaveral in Florida, Trump said the G7 in its current format was a “very outdated group of countries. 11.17am BSTA record number of Americans face hunger this year as the catastrophic economic fallout caused by the coronavirus pandemic looks set to leave tens of millions of people unable to buy enough food to feed their families.Nationwide, the demand for aid at food banks and pantries has soared since the virus forced the economy to be shutdown, resulting in more than 40m new unemployment benefit claims, according to the latest figures. 10.49am BSTDonald Trump has been forced to cancel a planned face to face Summit of leaders of the G7 nations in June and now wants to host an expanded meeting in September dedicated to combating China to which Vladimir Putin would be invited.Trump revealed on Saturday he had cancelled the June G7 meeting after Angela Merkel the German chancellor told him in a phone call that she saw the summit in Washington as a health risk. Normally hundreds of journalists and officials attend the two day summits, as well as security staff. He had billed the face to face summit as a symbol of America “transitioning back to greatness”. 10.37am BSTSpain’s prime minister has said he will ask parliament to agree to a last two-week extension of the state of emergency lockdown until 21st June, after which the government will no longer restrict citizens’ movements, El Pais reported.Pedro Sanchez told regional government leaders during a video-conference meeting on Sunday that this would be the last lockdown as Spain’s infection rates have reduced dramatically.El presidente del Gobierno se encuentra reunido mediante videoconferencia con los presidentes/as de las comunidades y ciudades aut�nomas. Tras este encuentro, @sanchezcastejon comparecer� ante los medios de comunicaci�n.#EsteVirusLoParamosUnidos pic.twitter.com/benRjMOBD2 10.14am BSTCanada is to invest 30 million Canadian dollars (US $21.8 million) to enable its provinces and territories to promote holidays in their “own back yard” because of the closure of the country’s borders due to the novel coronavirus pandemic.Destination Canada, the country’s national marketing body which usually focuses on luring international visitors, is due to announce the new funding later on Sunday, according to a statement seen by Reuters before its official release. 10.08am BSTThe Afghan health ministry has warned that a “catastrophe” is spreading across the war-torn country as number of confirmed coronavirus cases passed 15,000, amid continued surge of transmission in Kabul.Wahid Majroh, deputy health minister warned on Sunday that the virus was spreading as lockdown rules continued to be flouted.Meanwhile, the health ministry recorded 680 new cases and eight deaths of Covid-19 as more than of half of tests done in a 24-hour period came back positive across the country. It takes the total number of infections to 15,205 and death toll to 257. There have been 1,328 recoveries.Most of new cases recorded in the capital city of Kabul 371 patients tested positive, Kabul is the country’s worst affected area in number of transmissions with 6,146 confirmed cases and 30 deaths. 9.54am BSTThe Irish government is considering moves to speed up plans to ease the national lockdown, including brining forward plans to scrap limits on how far the public can travel from home.Museums, galleries, hairdressers and other amenities could also reopen by the end of June, while hotels could be allowed to operate with limited occupancies subject to the spread of Covid-19 remaining suppressed, the Sunday Independent reports. 9.47am BSTHong Kong’s 17-day run without a local coronavirus infection ended on Sunday as a woman with no recent travel history tested positive, the South China Morning Post reports, citing sources.Her husband also tested “preliminary” positive, it adds. 9.29am BSTParties and larger social gatherings have been blamed in Spain for spikes in infection that have caused regional problems for that country’s ongoing attempts to return to some level of normality, El Pais reports.In the western city of Badajoz, infections that are believed to have been picked up at a birthday party led to 18 people having to self-isolate, while there have been other small cases of inter-familiar infections at other social gatherings. 9.14am BSTFears that the easing of the lockdown in England could lead to a rise in infections after community transmission had been suppressed in recent weeks, have been expressed by a leading public health expert interviewed this morning on Sky news.Devi Sridhar, chair of global public health at Edinburgh University, asked by @SophyRidgeSky if she expects a rise in infections:"I’m very sorry to say that I think it is right now inevitable looking at the numbers, the only thing that might save England is the good weather." 9.05am BSTPolice across swathes of Africa have failed to find more than a fraction of hundreds of people who have escaped from often unsanitary and uncomfortable Covid-19 quarantine centres in recent weeks.There are more than 130,000 confirmed cases of Covid-19 in Africa, but low levels of testing means the true total is likely to be much higher, reports the Guardian’s Africa Correspondent Jason Burke and Nyasha Chingono in Harare. 8.51am BSTGovernment ministers in Britain have been accused of creating a “false sense of security” by launching a test and trace system that is not yet capable of controlling local outbreaks.A series of concerns have been raised over the gaps in the system launched last week, with local health chiefs warning that they have not been given the time, powers or data to prepare for outbreaks in their area. They said that they were given details of their roles just four working days before Matt Hancock, Britain’s health minister, launched test and trace last week. Related: Coronavirus test and trace system ‘creating false sense of security’ 8.48am BSTRussia has reported 9,268 new cases of the novel coronavirus, raising the national tally to 405,843.Officials said 138 people had died of COVID-19, the respiratory disease caused by the coronavirus, in the last 24 hours, pushing to nationwide toll up to 4,693. 8.43am BSTAmid unease and outright criticism from some scientific advisors to the British government about moves to ease the lockdown in England, the First Minister of Scotland’s devolved government has been emphasising the reasons for the more cautious approach being taken by her administration.Nicola Sturgeon, who attends meetings of a UK-wide committee of experts and political leaders convened by Britain’s prime minister, Boris Johnson, said the believed there was a concern on the part of some scientists that politicians had been seeking to blame them for mistakes that have been made in recent months. 8.30am BSTLarge number of mosques across Saudi Arabia have reopened for the first time in more than two months, but worshipers have been ordered to follow strict guidelines to prevent the spread of the coronavirus as Islam’s holiest site in Mecca remained closed to the public.The Al-Aqsa Mosque in Jerusalem, the third holiest site for Muslims after Saudi Arabia’s Mecca and Medina, also reopened for prayers for the first time since it was closed since mid-March. 8.26am BSTRwanda’s ministry of health on Sunday reported the East African nation’s first death caused by the new coronavirus, Reuters reports.The victim was a 65-year-old driver who opted to return home from a neighbouring country, where he resided, after falling severely ill, the ministry said in a statement. 8.24am BSTThe British government is coming under fresh pressure to drop plans which could see all primary schools in England returning to normal before the summer holidays.Ministers have said that five tests set for itself by the government before the easing of the lockdown have been met - and schools will admit more pupils in selected classes from Monday. 8.01am BSTThat’s it from me, Helen Sullivan for today. Many thanks to those of you who got in touch on Twitter and via email. Here are the key developments from the last few hours: Related: Coronavirus latest: at a glance 7.55am BSTGovernment regulations come into force tomorrow that will allow groups of up to six people to meet up outside, including in back gardens. After 10 long and monotonous weeks of social isolation, it’s the news that, if not everybody, then certainly sausage manufacturers have been dreaming of.“You can even have a barbecue,” announced prime minister Boris Johnson last week in one of those Churchillian moments of national spirit-raising for which he would like to be renowned. That is to say, you can chuck lighter fuel on the charcoal as long as your gathering is socially distanced, everyone washes their hands and exercises what Johnson called “common sense” – a disputed concept, these days; it may mean that if you don’t possess a barbecue set yourself, then you can drive 260 miles to see a family member who does have one. Related: Johnson-endorsed barbecues are getting a cool reception 7.42am BSTGet in touch on Twitter @helenrsullivan. 7.29am BST“The Trump presidency is over,” writes Robert Reich, a former US secretary of labor, and a professor of public policy at the University of California at Berkeley.By having no constructive response to any of the monumental crises now convulsing America, Trump has abdicated his office. He is not governing. He’s golfing, watching cable TV and tweeting. Related: Fire, pestilence and a country at war with itself: the Trump presidency is over | Robert Reich 7.14am BSTThe mayor of Atlanta, one of dozens of US cities hit by massive protests after the police killing of George Floyd, has a message for demonstrators: If you were out protesting last night, you probably need to go get a Covid test this week, AP reports. As emergency orders are lifted and beaches and businesses reopen, add protests to the list of concerns about a possible second wave of coronavirus outbreaks. It’s also an issue from Paris to Hong Kong, where anti-government protesters accuse police of using social distancing rules to break up their rallies.Health experts fear that silent carriers of the virus who have no symptoms could unwittingly infect others at gatherings with people packed cheek to jowl and cheering and jeering, many without masks. 7.03am BSTThroughout this pandemic, Boris Johnson has claimed to have been “following the science”. By parroting this epistemological nonsense, ministers are encouraging us to believe that they are only doing what the scientists tell them. It is but a short step from there to blaming the government’s scientific advisers for the UK’s terrible death toll. This lends added significance to the roll call of prominent scientists – including some senior members of the government’s scientific advisory committee for emergencies (Sage) – who have this weekend publicly made clear their concerns that the government is relaxing the lockdown in England too early. Related: The Observer view on the premature relaxation of the lockdown 6.50am BSTThe number of people infected by the coronavirus around the world has passed 6 million, as the pandemic forced Donald trump to postpone the G7 summit in Washington.More than 1.7 million of those cases have been registered in the United States, and its continued spread in the world’s richest nation has forced the US president to abandon plans to stage a G7 summit as his hoped-for sign of America’s recovery. Related: Global report: coronavirus cases pass 6 million as Donald Trump postpones G7 6.40am BSTSerious concerns are emerging over the treatment of children in custody during the coronavirus pandemic, after evidence that some have been spending as little as 40 minutes a day out of their cell.A series of “serious consequences for children’s rights, wellbeing and long-term outcomes” has been identified in an investigation by the office of the children’s commissioner for England. This comes with ministers warning that there is now an increased risk of self-harm and violence in adult prisons as a result of measures introduced to tackle Covid-19. Related: Covid causes child detention crisis, and a ‘timebomb’ in adult prisons 6.30am BSTOBSERVER: Top scientists: Cummings has broken trust in Covid policy #TomorrowsPapersToday pic.twitter.com/S6YZFZ6uP9INDEPENDENT ON SUNDAY: ‘Dangerous moment’ as lockdown warnings grow #TomorrowsPapersToday pic.twitter.com/oEjMv21OFeSUNDAY TIMES: Keep promises or face no deal ⁦@MichelBarnier⁩ tells ⁦@BorisJohnson⁩ #TomorrowsPapersToday pic.twitter.com/tZ9lIrU5R7SUNDAY TELEGRAPH: Officials ‘could only cope with five Covid cases a week’ #TomorrowsPapersToday pic.twitter.com/9nPNOSddotPEOPLE: Test and trace is national disgrace #TomorrowsPapersToday pic.twitter.com/f6ecv1Wi41MAIL ON SUNDAY: You couldn’t make it up #TomorrowsPapersToday pic.twitter.com/rQz5w3oKCDSUNDAY POST: Disaster planning #TomorrowsPapersToday pic.twitter.com/3hxGNiUXS1 6.17am BSTAutomatons have been chipping in with the effort to beat Covid, from disinfecting hospitals to delivering groceries. Related: The five: robots helping to tackle coronavirus 6.07am BSTThailand reported four new coronavirus cases on Sunday and no new deaths, taking the total number of infections to 3,081 with 57 deaths since January.The new patients had arrived in Thailand from the United Arab Emirates, Turkey, and Saudi Arabia and have been in state quarantine, said Panprapa Yongtrakul, a spokeswoman for the government’s Centre for Covid-19 Situation Administration.Local infections have slowed and over the last two weeks, around 80% of new cases were Thais who had returned from abroad, Panprapa added.Thailand will on Monday begin reopening more businesses classified as medium to high risks, including cinemas and gyms. 5.55am BSTSouth African President Cyril Ramaphosa faces a fresh leadership test over his handling of the coronavirus outbreak, AFP reports. Africa’s most industrialised nation is preparing to reopen its economy on Monday as it moves into level three of a five-tier lockdown, in force since 27 March, sowing bitter divisions. 5.46am BST 5.38am BSTThailand’s parliament is due Sunday to vote on whether to approve a near-US$60 billion stimulus to revive an economy battered by the pandemic.If agreed, it will be the biggest state cash injection in Thai history. 5.26am BSTSouth Korea has reported 27 new cases of the coronavirus, including 21 from the densely populated Seoul metropolitan area, where officials have been scrambling to stem transmissions linked to club-goers and warehouse workers, AP reports. The figures announced by South Korea’s Centers for Disease Control and Prevention on Sunday brought national totals to 11,468 cases and 270 deaths. Twelve of the new cases were linked to international arrivals. 5.16am BSTIndia is extending its ongoing lockdown in designated coronavirus containment zones until 30 June but will allow all economic activities to restart in a phased manner outside those areas as cases continue to rise in its major cities.India’s Home Ministry said in a directive issued Saturday that a reopening phase set to start Monday is called Unlock 1.The directive said religious sites and places of worship, hotels, restaurants and other hospitality services and shopping malls will be allowed to reopen outside all containment zones starting 8 June. 5.06am BSTNew Zealand has no new cases of coronavirus for the ninth day in a row, Stuff.nz reports. As at 9am on Sunday, 1504 cases of Covid-19 have been diagnosed in the country, 1154 of which were confirmed by tests. The other 350 were “probable” cases of the illness.Just one person – who is in their 50s and linked to the St Margaret’s Hospital and Rest Home cluster in Auckland – is believed to have an “active” case of the illness. That person is not in hospital. 4.42am BSTThe number of confirmed coronavirus cases in Germany increased by 286 to 181,482, data from the Robert Koch Institute (RKI) for infectious diseases showed on Friday.The reported death toll rose by 11 to 8,500, the data showed. 4.25am BSTBrazil has surpassed France’s death toll, after it reached 28,834 coronavirus fatalities, becoming the country with the world’s fourth-highest death toll.Sao Paulo and Rio de Janeiro remain the hardest-hit states in Brazil in terms of sheer numbers, while per capita rates are higher in the country’s impoverished north and northeast, where health facilities are reaching capacity. 4.14am BSTThe Covid-19 pandemic has seen a ferocious competition erupt between China and the US, the UN’s two main contributors, fuelling paralysis according to diplomats, AFP reports. After more than two months of negotiations, the 15 Security Council members were unable to reach agreement on a resolution supporting a call from the UN secretary-general for a global cease-fire while the world battles the novel coronavirus. 4.03am BSTOnto Australia’s economy now. Shadow treasurer Jim Chalmers says even if this week’s economic growth numbers prove to be positive, there is little doubt Australia is in a recession that has ended 29 consecutive years of expansion, AAP reports. 3.43am BSTHammered by the health crisis, China’s economy shrank 6.8% in the first quarter from a year earlier, the first contraction since quarterly records began. Analysts believe it will be months before broader activity returns to pre-crisis levels, even if a fresh wave of infections can be avoided, Reuters reports. While most businesses have reopened, many manufacturers are struggling with reduced or cancelled overseas orders as lockdowns push the global economy into recession. Domestic demand also remains depressed amid increased job losses and worries about a second wave of infections.Factories reduced headcount for the first time since they reopened, with a sub-index falling to 49.4 from 50.2 in April, the survey showed.Highlighting the uncertain outlook, the government’s work report earlier this month did not set an annual growth goal, marking the first time China has not set a target since 2002.Beijing also announced additional fiscal measures to bolster the economy, equal to about 4.1% of China’s gross domestic product (GDP), according to Reuters calculations, its largest stimulus package since the global financial crisis. 3.30am BSTChina recorded two new confirmed cases of coronavirus on 30 May, down from four the day before, data from the country’s health authority showed on Sunday.Both cases were imported in the Chinese province of Shandong, the National Health Commission (NHC) said in a statement on its website.The NHC also confirmed three new asymptomatic cases, compared to four the day before.With no new deaths reported, the death toll remained at 4,634.The total number of confirmed cases in the mainland as of May 30 stood at 83,001, data form NHC showed. 3.25am BSTMexico on Saturday registered 2,885 new cases of coronavirus and 364 more deaths, bringing the total numbers to 87,512 cases and 9,779 fatalities, according to data from health authorities. 3.09am BSTJerusalem’s Al-Aqsa mosque reopened to worshippers on Sunday after a two-and-a-half month coronavirus closure, but Muslim authorities imposed some precautions as health officials warn of an uptick in local infections.The resumption of prayers at Islam’s third-holiest site caps a sombre period for Jerusalem’s Muslims, who this year marked the holy fasting month of Ramadan and the Eid al-Fitr holiday without their usual daily visits to Al-Aqsa and the adjoining Dome of the Rock.The Council of Islamic Waqf cited the slowed local spread of Covid-19 in lifting entry restrictions and reopening the compound’s iconic shrines, which shut on 15 March. 2.57am BSTActivity in China’s services sector expanded at a faster clip in May as measures to contain the coronavirus outbreak were lifted, official data showed on Sunday, suggesting business and consumer confidence may slowly be improving, Reuters reports. 2.49am BSTGet in touch on Twitter @helenrsullivan. 2.44am BSTIn the US, Los Angeles, which has shut down its Covid-19 testing centres in response to escalating protests, remains the primary hotspot for coronavirus cases in California, and the county announced 2,112 new cases and 48 deaths on Saturday. 2.38am BSTThe Australian states of Victoria and New South Wales, meanwhile, have recorded six and three new cases of Covid-19 respectively.In NSW, all three cases are recently returned travellers who are currently in mandatory hotel quarantine.In Victoria, the health minister Jenny Mikakos has just given an update to media on the six new cases. She said two of the cases are linked to a family outbreak in the Keilor Downs area of the state.There has also been another case recorded flowing from an outbreak linked to a Rydges Hotel in Melbourne which has been hosting returned travellers in mandatory quarantine. 2.33am BSTIn Australia, the Queensland state premier, Annastacia Palaszczuk, has just announced the state will bring forward the easing of Covid-19 restrictions within the state, allowing gatherings of up to 20 people and travel within the state. Speaking just now Palaszczuk said that from 1 June (so, tomorrow) restrictions banning recreational travel within Queensland will be lifted. Or, as she described it, “opening up Queensland for Queenslanders”. She also said that from tomorrow cafes, restaurants and bars in Queensland will be able to hold 20 people. JUST IN: Here’s our latest roadmap to easing restrictions. From tomorrow, we're opening Queensland for Queenslanders. https://t.co/SqGYiangpX #covid19 #qldjobs pic.twitter.com/zMPKvDDARJ 2.27am BSTIn the US, KTLA news is reporting that coronavirus testing centres in Los Angeles, California have been closed as a result of the protests. KTLA reports: Los Angeles Mayor Eric Garcetti said that all COVID-19 testing centers in the city closed Saturday afternoon due to safety concerns as protests against the killing of George Floyd continued throughout the city.“We need to make sure, especially in communities that have less power, that we are able to make sure people don’t disproportionately die because of the color of their skin,” the mayor said. “We can’t do that when the city breaks down.” 2.19am BSTBelow is a roundup of the latest on the protests in the US. A reminder that we have ongoing live coverage of the unrest here. Related: George Floyd: protests spread as US cities announce curfews amid unrest 2.18am BSTUS president Donald Trump has postponed the Group of Seven summit that he wanted to hold in June and will also expand the list of countries invited to attend the rescheduled event to include Australia, Russia, South Korea and India. Speaking to reporters on Air Force One during his return to Washington from Cape Canaveral in Florida, Trump said the G7 in its current format was a “very outdated group of countries”. Related: Donald Trump postpones G7 summit and signals wider attendance list in future 2.04am BSTIn Australia, the New South Wales state government will walk away from its planned AU$810m (US$540m) redevelopment of the former Olympic stadium in Sydney as the state grapples with the economic fallout from the coronavirus pandemic.On Sunday the premier, Gladys Berejiklian, will announce that the state government will dump the stadium redevelopment, a key but controversial plank of its election pitch last year, instead announcing a AU$3bn fund for smaller, “shovel-ready projects”. Related: NSW government dumps Olympic stadium redevelopment as Covid-19 restrictions set to ease 1.53am BSTThe more than 2 million people who have been “shielding” from Covid-19 in England because they are deemed to be clinically extremely vulnerable will be allowed to spend time outdoors from Monday for the first time in 10 weeks.Boris Johnson praised their resilience as their particular lockdown measures are set to be eased. The communities secretary, Robert Jenrick, will confirm the move on Sunday. Related: Lockdown to be eased for England's most clinically vulnerable 1.42am BSTIn case you missed this earlier, in Australia, residents in the country’s most populous state, New South Wales, are enduring one more day of tight Covid restrictions before pubs, beauty salons and museums reopen and intrastate holiday travel is permitted, AAP reports.For the first time in almost three weeks, zero Covid-19 cases were reported in NSW on Saturday, from 9500 tests. 1.34am BSTThere are signs that thousands of Australians used the coronavirus shutdown to give up smoking, AAP reports. Federal health Minister Greg Hunt says between January and May this year, the My Quitbuddy app was downloaded more than 24,000 times, a staggering 310% increase over the same time last year. 1.25am BSTBrazil has nearly 500,000 cases, after a record one-day increase. Brazil registered a record 33,274 new cases of the novel coronavirus on Saturday, its health ministry said, raising the total to 498,440 in a country with one of the world’s worst outbreaks. 1.19am BSTThe world has passed the milestone of six million confirmed coronavirus cases, with 6,048,384 confirmed infections worldwide, according to the Johns Hopkins University tracker.The US is the worst-affected country in terms of cases and deaths, with 1,769,776 infections and 103,685 fatalities. 1.16am BSTHello and welcome to today’s live coverage of the coronavirus pandemic. I’m Helen Sullivan, bringing you the latest global news for the next few hours. Please do get in touch on Twitter @helenrsullivan or via email: helen.sullivan[at]theguardian.com. Questions, comments, tips and news from your part of the world are all welcome. Continue reading... http://creativecommons.org/licenses/by-nc-sa/3.0/ African nations fail to find coronavirus quarantine escapees https://www.theguardian.com/world/2020/may/31/african-nations-fail-to-find-coronavirus-quarantine-escapees https://www.theguardian.com/world/2020/may/31/african-nations-fail-to-find-coronavirus-quarantine-escapees Sun, 31 May 2020 08:00:06 UTC Jason Burke in Johannesburg and Nyasha Chingono in Harare at Medical research | The Guardian There are more than 130,000 confirmed cases of Covid-19 in the continentCoronavirus – latest updatesSee all our coronavirus coveragePolice�across swathes of Africa�have failed to find more than a fraction of�hundreds of people who�have escaped from often unsanitary and uncomfortable�Covid-19 quarantine centres�in recent weeks.There are more than 130,000 confirmed cases of Covid-19 in Africa, but low levels of testing means the true total is likely to be much higher. Continue reading... http://creativecommons.org/licenses/by-nc-sa/3.0/ Did a coronavirus cause the pandemic that killed Queen Victoria's heir? https://www.theguardian.com/world/2020/may/31/did-a-coronavirus-cause-the-pandemic-that-killed-queen-victorias-heir https://www.theguardian.com/world/2020/may/31/did-a-coronavirus-cause-the-pandemic-that-killed-queen-victorias-heir Sun, 31 May 2020 07:17:05 UTC Robin McKie at Medical research | The Guardian The Great Russian Flu of the early 1890s may have been a Covid-like virus that crossed to humans from cows, scientists suggestCoronavirus – latest updatesSee all our coronavirus coverageThe epidemic spread with startling speed. It appeared first in London and within weeks had swept Britain. Thousands died of respiratory illness, the prime minister was laid low, and employees’ sickness disrupted industry and transport.�It sounds familiar. Yet this epidemic erupted in 1891 when waves of disease swept round the globe, eventually killing more than a million people. The outbreak was later attributed to flu and dubbed the Great Russian Flu pandemic.Many 1890 patients suffered central nervous system damage – rare in influenza but common in today's Covid-19 pandemic Continue reading... http://creativecommons.org/licenses/by-nc-sa/3.0/ The Observer view on the premature relaxation of the lockdown https://www.theguardian.com/commentisfree/2020/may/31/the-observer-view-on-the-premature-relaxation-of-the-lockdown https://www.theguardian.com/commentisfree/2020/may/31/the-observer-view-on-the-premature-relaxation-of-the-lockdown Sun, 31 May 2020 05:00:03 UTC Observer editorial at Medical research | The Guardian Boris Johnson’s lack of transparency suggests he is more concerned with a political crisis than a health oneCoronavirus – latest updatesSee all our coronavirus coverageThroughout this pandemic, Boris Johnson has claimed to have been “following the science”. By parroting this epistemological nonsense, ministers are encouraging us to believe that they are only doing what the scientists tell them. It is but a short step from there to blaming the government’s scientific advisers for the UK’s terrible death toll. This lends added significance to the roll call of prominent scientists – including some senior members of the government’s scientific advisory committee for emergencies (Sage) – who have this weekend publicly made clear their concerns that the government is relaxing the lockdown in England too early.The decision about when and how to relax the lockdown is political. It can only ever be informed, not dictated, by the uncertain science, and must also weigh the risks and costs imposed by the lockdown itself. This is why it is critical that politicians are unfailingly transparent about the basis on which they are making their decisions – not just the scientific advice, but the other assumptions and value judgments that are informing their decisions.Johnson has made a conscious decision to rubbish the integrity of the government’s public health message Continue reading... http://creativecommons.org/licenses/by-nc-sa/3.0/ Polypharmacy and deprescribing https://www.medicinejournal.co.uk/article/S1357-3039(20)30078-5/fulltext?rss=yes https://www.medicinejournal.co.uk/article/S1357-3039(20)30078-5/fulltext?rss=yes Sun, 31 May 2020 00:00:00 UTC Rupert A. Payne at Medicine Polypharmacy is a common issue in clinical practice, with 20% of adults given ≥5 regular medications. It particularly impacts elderly individuals and those with multiple morbidities, and is worsened by single-disease, guideline-driven prescribing and service pressures. Although sometimes appropriate, it can also be problematic, associated with a range of adverse outcomes including hazardous prescribing, excess treatment burden, poor quality of life, higher health service use, and increased morbidity and mortality. http://creativecommons.org/licenses/by-nc-sa/3.0/ Could nearly half of those with Covid-19 have no idea they are infected? https://www.theguardian.com/world/2020/may/30/could-nearly-half-of-those-with-covid-19-have-no-idea-they-are-infected https://www.theguardian.com/world/2020/may/30/could-nearly-half-of-those-with-covid-19-have-no-idea-they-are-infected Sat, 30 May 2020 14:00:45 UTC David Cox at Medical research | The Guardian As studies confirm many infected people show no symptoms, contact tracing and face masks assume even greater importance Coronavirus – latest updatesSee all our coronavirus coverageWhen Noopur Raje’s husband fell critically ill with Covid-19 in mid-March, she did not suspect that she too was infected with the virus.Raje, an oncologist at Massachusetts General Hospital in Boston, had been caring for her sick husband for a week before driving him to an emergency centre with a persistently high fever. But after she herself had a diagnostic PCR test – which looks for traces of the Sars-CoV-2 virus DNA in saliva – she was astounded to find that the result was positive.You don’t need to be coughing to transmit a respiratory infection: talking, singing, even blowing a vuvuzela… Continue reading... http://creativecommons.org/licenses/by-nc-sa/3.0/